An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates.
نویسندگان
چکیده
The stable Pd(0) species [(1,5-cyclooctadiene)(L·Pd)2] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 15 21 شماره
صفحات -
تاریخ انتشار 2013